Skin Regeneration Laboratry
A state-of-the- art Skin Regeneration Lab. has been set up with the following Aims and Objectives.

Translational Research:
  • Development of indigenous and cost effective dermal matrix which can be used as a dermal scaffold for cell based tissue engineered skin substitutes.
  • Development of autologous and allogenic cell (keratinocytes, Fibroblasts, melanocytes, Mesenchymal stem cells (MSCs)) based therapy in conjunction with composite Biomaterials to resurface extensive deep 2nd degree and 3rd Degree burns.
  • Development of noble autologous cell transfer technology from cell culture laboratory on to burn wound.
  • Development of treatment options for post burn hypo-pigmentation using autologous melanocyte cell culture.
  • Exploring the possible use of stem cells on speedy burn-wound healing.
Basic Research:
  • Development of in-vitro 3D Human skin equivalent model (HSE) to use it as a tool to understand the biology of wound healing ex-vivo and to study affect of different healing agents in the wound healing process and to formulate new treatment options for faster and scar free burns wound healing process.
  • Study of post burn hypotrophic scar and understanding the biology of abnormal scar formation and its reversal process.
The Problem Statement:

As per the 2012 data of Union health ministry of India, Our Country records 70 lakh burn injury cases annually of which 1.4 lakh people die every year. Around 70% of all burn injuries occur in the most productive age group (15-35 yrs). Around four out of five burnt cases are women and children.

This may be the tip of the ice berg as all burns incidents are medico legal cases as per the law. So most of the burns cases are not reported to the police . And India does not have a National Burns Registry.

As many as 80% of cases admitted are a result of accidents at kitchen-related accidents. Amongst all traumas, burn cases have highest duration of hospital bed occupancy. Cost of hospitalized burn injury case management is extremely high which may cost enormous financial burden to the country. The rehabilitation of the individual may be a challenging and daunting task.

The major causes of burns in our country are:
1 Unsafe cooking practices
2 Vehicle accidents related burns
3 Dowry related homicidal and Suicidal burns.
4 Crackers burns
5 Industrial burns
6 Electrical burns
7 Spillage of hot water on children and women

It is seen that in India, proper safely guidelines are not followed by the workers in the industrial areas. In industrial area flame, electrical, chemical, or oil burst are common causes of burns. Domestic accidents occurs during cooking, handling the water heating units and due to accidental spilling of hot liquids on the infants. Besides these suicidal and homicidal cases of burns are still prevalent in our country.

In such cases of extensive deep burns, the skin which acts as a barrier is burnt and the body is wide open to external infectious agents. Unless the dead skin of the burnt area is replaced with patient’s own skin, the burn wound does not get healed of its own. Prolonged exposure of non healing burn wound to external environment leads to microbial infection. As a result the patient dies of severe infection. In event of burns affecting less than 50% of body area, the skin from the un burnt area is sufficient to resurface burnt area. When the area is more than 50% of total body surface area then the patient does not have enough skin to cover the burnt area, in such cases there is a need of tissue engineered skin substitute or other noble burn wound resurfacing methods to save the life of burns patients. Looking at this scenario we have set up the translational research facility to address the above problem statement through indigenous, innovative, and most importantly cost effective research solution. which can become a life saving treatment option for extensively burn patients.

Tissue-engineered skin substitute is a significant advancement in the field of wound healing and was developed due to limitations associated with the use of autografts. These limitations include the creation of a donor site which is at risk of developing pain, scarring, infection and/or slow healing. Many skin substitutes have been in clinical use but not without any disadvantages. As a result different research group around the glove are still to find out the so called ideal skin substitute. The potential risks and benefits of using tissue-engineered skin need to be further evaluated in clinical trials but it is obvious that they offer a new option for the treatment of wounds.

A number of dermal substrates and bilayered skin substitutes with or without skin cells are commercially available and many others are in development. They certainly help in the treatment of burns but the cost is exponentially high. On the contrary it is observed that most of the burns victims in India are from the lower economic strata of the society who just cannot afford such expensive treatment. This makes our work more challenging to find out an effective research product which is cost effective . This project will result in the development of cost effective skin substitute. In addition this is going to help recovery & decrease of mortality of severely burnt patients.

The Problem Statement:

In future we are planning to work on stem cells and its therapeutic use in the management of burns and to develop an ideal and cost effective cell based skin substitute to resurface extensive deep burns injury.

With this set of world class infrastructure and dedicated human resource we are confident of bringing a revolution in burns injury treatment in India

Vision for Burns Research in India at National Burns Centre

Tissue Engineered Skin substitutes- with synthetic or bio-material based dermal matrices to make a composite skin graft.

Bio-skin bank to cater to National need

Stem cell based composite skin graft.

Our Research Team

Principal Investigator
Dr. Sunil Keswani (Medical Director, NBC)
Research Scientists
Mrs. Sangita Panda
Research Associates
Reshmi Verghese
Sr. Biotechnologist
Mrs. Archna Singh
Jr. Research Officer
Ms. Jasmeet Kaur Virdi
Ms. Tanvi Virkar
Mrs. Urja Desai
Ms. Vaishna Upendran
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